Atopic March. Risk of developing of allegic rinitis and bronchial asthma in children with atopic dermatitis

L.D. Ksenzova

Medical center “Institute of Allergology and Clinical Immunology”, Moscow, Russia

ALLERGOLOGY AND IMMUNOLOGY IN PEDIATRICS, Volume 55 • Number 4 • December 2018, pp. 25 – 30
DOI: 10.24411/2500-1175-2018-00019

The article gives a definition of an atopic march which refers to the typical progression of atopic diseases: when a patient has atopic dermatitis, as they get older they also develop allergic rhinitis and bronchial asthma. The existing hypotheses of development of an atopic march as well as the latest research the results of which contradict the long held perceptions about this phenomenon are analyzed. The analysis presented in the article makes one consider a possibility of forecast of development of such conditions and the necessity of further research seeking to understand the process of progress of atopic diseases, to determine their markers and the possibility of prognosis of their manifestations and, correspondingly, the possiblity of their prevention.

  1. The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma / Tao Zheng et al. // Allergy Asthma Immunol. Res. 2011. Apr. Vol. 3, № 2. P. 67–73.
  2. Nutten S. Atopic dermatitis: global epidemiology and risk factors // Ann. Nutr. Metab. 2015. Vol. 66, № 1. P. 8–16.
  3. Атопический дерматит у детей. Некоторые проблемы диагностики и лечения / А.В. Кудрявцева, Ф.С. Флуер, Ю.А. Богусловская и др. // Педиатрия. 2017. Т. 96, № 2. С. 227–231.
  4. Балаболкин И.И., Булгакова В.А., Елисеева Т.И. Иммунопатогенез и современные возможности терапии атопического дерматита у детей // Аллергология и иммунология в педиатрии. 2017. № 2 (49). С. 12–22.
  5. Определение уровня экспрессии антимикробных пептидов у пациентов с атопическим дерматитом / П.В. Жигалкина, А.В. Кудрявцева, К.А. Нескородова и др. // Научный форум: Инновационная наука: сб. ст. по материалам II междунар. науч.-практ. конф. № 1 (2). М.: Изд. МЦНО, 2017. С. 5–9.
  6. Thymic stromal lymphopoietin: a promising therapeutic target for allergic disease / W.L. Wang et al. // Int. Arch. Allergy Immunol. 2013. Vol. 160. P.18–26.
  7. Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies / Belgrave D.C.M. et al. // PLoS Med. 2014. Oct. Vol. 21, № 11 (10):e1001748. DOI: 10.1371/journal.pmed.1001748. eCollection 2014 Oct.
  8. Simpson E.L. Comorbidity in Atopic Dermatitis. Curr. Dermatol. Rep. 2012. Mar. Vol. 1, № 1 (1). P. 29–38.
  9. Risk factors for the development of atopic dermatitis and early wheeze / I. Stelmach et al. Allergy Asthma Proc. 2014.35:382–389.
  10. Variations in risk of asthma and seasonal allergies between early- and late-onset pediatric atopic dermatitis: a cohort study / J. Wan et al. // J. Am. Acad. Dermatol. 2017. Vol. 77, № 4. P. 634–640
  11. Development of allergies and asthma in infants and young children with atopic dermatitis – a prospective follow-up to 7 years of age / D. Gustafsson et al. // Allergy. 2000. Vol. 55. Р. 240–245.
  12. Risk of Developing asthma in young with atopic eczema: a systematic reviw / A.E. van der Hulst et al. // J. Allergy Clin. Immunol. 2007. Vol. 120. Р. 565–569.
  13. Eczema in childhood is strongly associated with the Development of asthma and rhinitis in a prospective cohort / L.B. von Kobyletski et al. // BMC Dermatol. 2012. 12:11.
  14. Early eczema in the risk of childhoodasthma: a prospective, population-based study / M. Saunes et al. // BMC Pediatr. 2012; № 12. Р. 168

Ksenzova LD. Atopic March. Risk of developing of allegic rinitis and bronchial asthma in children with atopic dermatitis. Allergology and Immunology in Pediatrics. 2018;55(4):25-30. (In Russ.)

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L.D. Ksenzova


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