Dynamics of changes in the concentration of peroxides in the blood in atopic dermatitis in children

E.S. Slusareva ^1,2, E.V. Dudnikova ¹, A.U. Nurtazina ³, A.V. Kudryavtseva ^3,4

¹Rostov State Medical University, Rostov-on-Don, Russia;
²State Budgetary Institution of Rostov Region «Regional Pediatric Teaching Hospital», Rostov-on-Don, Russia;
³I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
⁴Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia;

AALLERGOLOGY AND IMMUNOLOGY IN PEDIATRICS, Volume 59 • Number 4 • December 2019, pp. 14 – 21
DOI: 10.24411/2500-1175-2019-00018

Abstract

The article discusses the way the oxidative stress is involved in development of acute and chronic forms of the Atopic Dermatitis (AtD). We have examined 67 young AtD patients (on average aged 29 [16; 43] months) living in the city of Rostov-on-Don and included them in three groups depending on the clinical forms of the disorder: 36 patients with the exudative form (EX), 25 with the erythematosquamous form (ErS) and 6 patients having the erythematosquamous form with lichenification (ErSL). We have examined dynamics of the oxidative status during AtD exacerbation and in remission through measuring peroxides in EDTA blood serum samples by the colorimetric method in the microplate format (BiomedicaOxyStat test systems (Austria)). When examining the oxidative status in children having ErSL form of AtD, we have noted the reliably highest level of the bio peroxides vs. EX and ErS forms. In remission, patients having ErSL form of AtD have retained the reliably higher level of bio peroxides vs. EX and ErS clinical forms (р=0,045), thus implying unstable remission in children having chronic forms of the disorder and featuring higher risk of AtD exacerbations in future as compared to the children having acute forms of the disorder.
Thus, dynamics of concentration of bio peroxides in the blood serum of children having EX, ErS and ErSL clinical forms of AtD during AtD exacerbation and in remission reflects involvement of the oxidative stress in development of more chronic forms of AtD.

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Slusareva ES, Dudnikova EV, Nurtazina AU, Kudryavtseva AV. Dynamics of changes in the concentration of peroxides in the blood in atopic dermatitis in children. Allergology and Immunology in Pediatrics. 2019;59(4):4-21. (In Russ.) https://doi.org/10.24411/2500-1175-2019-00018

For correspondense

E.S. Slusareva
e-mail: 89081751306@yandex.ru.

E.V. Dudnikova
e-mail: 89081751306@yandex.ru.

A.U. Nurtazina
e-mail: asel26nurtazina@mail.ru.

A.V. Kudryavtseva
e-mail: kudassia@gmail.com.