Dynamics of changes in the concentration of peroxides in the blood in atopic dermatitis in children

E.S. Slusareva 1,2, E.V. Dudnikova 1, A.U. Nurtazina 3, A.V. Kudryavtseva 3,4

1 Rostov State Medical University, Rostov-on-Don, Russia;
2 State Budgetary Institution of Rostov Region «Regional Pediatric Teaching Hospital», Rostov-on-Don, Russia;
3 I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
4 Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia;


AALLERGOLOGY AND IMMUNOLOGY IN PEDIATRICS, Volume 59 • Number 4 • December 2019, pp. 14 – 21
DOI: 10.24411/2500-1175-2019-00018

The article discusses the way the oxidative stress is involved in development of acute and chronic forms of the Atopic Dermatitis (AtD). We have examined 67 young AtD patients (on average aged 29 [16; 43] months) living in the city of Rostov-on-Don and included them in three groups depending on the clinical forms of the disorder: 36 patients with the exudative form (EX), 25 with the erythematosquamous form (ErS) and 6 patients having the erythematosquamous form with lichenification (ErSL). We have examined dynamics of the oxidative status during AtD exacerbation and in remission through measuring peroxides in EDTA blood serum samples by the colorimetric method in the microplate format (BiomedicaOxyStat test systems (Austria)). When examining the oxidative status in children having ErSL form of AtD, we have noted the reliably highest level of the bio peroxides vs. EX and ErS forms. In remission, patients having ErSL form of AtD have retained the reliably higher level of bio peroxides vs. EX and ErS clinical forms (р=0,045), thus implying unstable remission in children having chronic forms of the disorder and featuring higher risk of AtD exacerbations in future as compared to the children having acute forms of the disorder.
Thus, dynamics of concentration of bio peroxides in the blood serum of children having EX, ErS and ErSL clinical forms of AtD during AtD exacerbation and in remission reflects involvement of the oxidative stress in development of more chronic forms of AtD.

  1. Мингалиев Р.А., Кудрявцева А.В. Атопический дерматит у детей как мультифакториальное заболевание, причины возникновения и особенности лечения. Аллергология и иммунология в педиатрии. 2017; 1 (48): 8–14.
  2. Смирнова Г.И. Управление течением болезни: атопический дерматит у детей // Российский педиатрический журнал. 2014; 6: 45–53.
  3. Ji H., Li X.K., Oxidative stress in atopic dermatitis //Oxidative medicine and cellular longevity.2016; 6: 1–8.
  4. Halliwell B., Gutteridge J.M.C., Cross C.E., Free radicals, antioxidants, and human disease: where are we now?// The Journal of Laboratory and Clinical Medicine. 1992; 119 (6): 598–620.
  5. Liguori I., Russo G., Curcio F., Bulli G. Oxidative stress, aging, and diseases// Clinical interventions in aging. 2018; 13: 757–772.
  6. Kannan K., Jain S.K., Oxidative stress and apoptosis//Pathophysiology. 2000; 7(3): 53–163.
  7. Omata N., Tsukahara H., Ito S., Ohshima Y., Increased oxidative stress in childhood atopic dermatitis//Life Sciences. 2001; 69 (2): 223–228.
  8. Chung J., Oh S.-Y., Shin Y.-K. Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children// Clinical Chemistry and LaboratoryMedicine. 2009; 47(12): 1475–1481.
  9. Amin M.N., Liza K.F., Sarwar M.S., Ahmed J. Effect of lipid peroxidation, antioxidants, macro minerals and trace elements on eczema Archives of Dermatological Research. 2015; 307(7): 617–623.
  10. Sivaranjani N., VenkataRao S., Rajeev G. Role of reactive oxygen species and antioxidants in atopic dermatitis// Journal of Clinical and Diagnostic Research. 2013; 7(12): 2683–2685.
  11. Tsukaharaet H. et al. Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis/ Life Sciences. 2003; 72(22): 2509–2516.
  12. Mohan G.C., Silverberg J.I. Association of vitiligo and alopecia areata with atopic dermatitis: a systematic review and meta-analysis// JAMA Dermatology. 2015; 151(5): 522–528.
  13. Nakai K., Yoneda K., Maeda R., Munehiro A. Urinary biomarker of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis//Journal of the European Academy of Dermatology and Venereolog. 2009; 23(12): 1405–1408.
  14. Shibama S., Ugajin T., Yokozeki H. Bilirubin oxidation derived from oxidative stress is associated with disease severity of atopic dermatitis in adults//Clinical and experimental dermatology. 2019; 44(2): 153–160.
  15. Manti S., Marseglia L., D’Angelo G., Cuppari C. “Cumulative Stress”: the effects of maternal and neonatal oxidative stress and oxidative stress-inducible genes on programming of atopy//Oxidative medicine and cellular longevity. 2016; 2016: 1–8.
  16. Chang H.Y., Suh D.I., Yang S.-I., Kang M.-J. Prenatal maternal distress affects atopic dermatitis in offspring mediated by oxidative stress //Journal of Allergy and Clinical Immunology. 2016; 138(2): 468–475.
  17. Копытова Т.В., Пантелеева Г.А., Дмитриева О.Н., Коткова Е.В. Оценка окислительной модификации белков у больных хроническими распространенными дерматозами. Клиническая лабораторная диагностика. 2014; 59(2): 41–44.
  18. Щелчкова Н.А., Копытова Т.В., Химкина Л.Н., Пантелеева Г.А. 8-он-2′-дезоксигуанозин как маркер окислительной модификации ДНК у больных хроническими распространенными дерматозами. Клиническая лабораторная диагностика. 2013; 1: 34–36.
  19. Sol I.S., Kim Y.H., Lee K.E., Hong J.Y. Serum clusterin level in children with atopic dermatitis. Allergy & Asthma Proceedings. 2016; 37(4): 335–339.
    20. Amin M.N., Liza K.F., Sarwar M.S., Ahmed J. Effect of lipid peroxidation, antioxidants, macro minerals and trace elements on eczema// Archives of DermatologicalResearch. 2015; 307(7.): 617–623.
  20. Sivaranjani N., Venkata Rao S., Rajeev G. Role of reactive oxygen species and antioxidants in atopic dermatitis// Journal of Clinical and Diagnostic Research. 2013; 7(12): 2683–2685.
  21. Shibama S., Ugajin T., Yokozeki H. Bilirubin oxidation derived from oxidative stress is associated with disease severity of atopic dermatitis in adults//Clinical and experimental dermatology. 2019; 44(2): 153–160.
  22. Tsukahara H., Shibata R., Ohshima Y., Todoroki Y. Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis// Life sciences. 2003; 72: 2509–2516.

Slusareva ES, Dudnikova EV, Nurtazina AU, Kudryavtseva AV. Dynamics of changes in the concentration of peroxides in the blood in atopic dermatitis in children. Allergology and Immunology in Pediatrics. 2019;59(4):4-21. (In Russ.) https://doi.org/10.24411/2500-1175-2019-00018

For correspondense

E.S. Slusareva
e-mail: 89081751306@yandex.ru.

E.V. Dudnikova
e-mail: 89081751306@yandex.ru.

A.U. Nurtazina
e-mail: asel26nurtazina@mail.ru.

A.V. Kudryavtseva
e-mail: kudassia@gmail.com.

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