Analysis of the results of the mantoux test with 2 TE in children with rheumatoid arthritis when prescribing genetically engineered drugs

M.V. Uraksina, E.A. Amosova, B.E. Borodulin

Federal State Budgetary Educational Institution of Higher Education «Samara State Medical University» of the Ministry of Health of the Russia Federation, Samara

ALLERGOLOGY AND IMMUNOLOGY IN PEDIATRICS, Volume 60 • Number 1 • March 2020, pp. 44 – 48
DOI: 10.24411/2500-1175-2020-10003

Questions of early detection of tuberculosis infection in children with rheumatoid arthritis (RA) are of particular relevance when prescribing basic therapy with genetically engineered biological drugs (GEBD). At the same time, all of them are at twice the risk of tuberculosis, both for the disease itself and for the treatment used. The article presents the results of a survey of 121 children aged 1 to 7 years. Two groups were formed: the first group (main group) included 53 patients with rheumatoid arthritis, and the second (comparison group) — 68 children without rheumatoid arthritis. A comparative analysis of the data from the annual Mantoux test was carried out, an additional test with Diaskintest was conducted for differential diagnosis of vaccine and infectious allergies, and risk factors for tuberculosis were studied.
In children with JIA, an ineffective BCG vaccination is more often observed, the size of the scar significantly differs in smaller sizes. When evaluating the samples, low sensitivity to tuberculin in the Mantoux test with 2 TE prevails over moderate and high compared with the control group. In a comparative analysis of tuberculosis risk factors, social factors were almost the same (37.7%—32.3%, respectively).

The use of Diaskintest excludes active tuberculosis infection in case of negative results, expanding the possibilities for prescribing
GEBD in children with RA.

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Uraksina MV, Amosova EA, Borodulin BE. Analysis of the results of thetuberculin test with 2 TE in children with rheumatoid arthritis when prescribing genetically engineered drugs. Allergology and Immunology in Pediatrics. 2020;60(1):44-48. (In Russ.) https://doi 10.24411/2500-1175-2020-10003

For correspondense

Maria V. Uraksina, resident of the Department of phthisiology and pulmonology of FSBEI of HE «Samara SMU» of the Ministry of Health of the Russia Federation
Address: 89 Chapayevskaya str., Samara, 443099, Russia
E-mail: mashka05-94@mail.ru

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