Antileukotriene drugs in complex treatment of recurrent laryngotracheitis in children with allergic diseases for prevention of lower respiratory airways obstruction

A.G. Chuvirova, M.N. Yartsev

SSC «Institute of Immunology FMBA», Moscow, Russia

ALLERGOLOGY AND IMMUNOLOGY IN PEDIATRICS, Volume 64 • Number 1 • March 2021, pp. 44-52
DOI: 10.24412/2500-1175-2021-1-44-52

We studied the possibility of prescribing antileukotriene drugs in children with recurrent laryngotracheitis for the prevention of bronchial obstruction. Examined 120 children (71 boys and 49 girls) with recurrent laryngotracheitis at the age of 3–9 years at the beginning of observation. Allergic diseases (allergic rhinitis, atopic dermatitis) were diagnosed in 80 children, divided into groups Ia and II of 40 people, respectively, before inclusion in the study. The level of total serum IgE in children ranged from 50 to 2000 IU/ml, polysensitization was noted (to household, pollen, fungal allergens). Patients of the I-st group received therapy according to the standards of treatment for obstructive laryngotracheitis. Group II, consisting of 40 patients with allergic deseases, additionally received 2 months montelukast courses trice a year, in periods without episodes of recurrent laryngotracheitis. For 3 years of follow-up, it was possible to determine groups of children with recurrent laryngotracheitis in combination with repeated bronchitis with obstructive component (50%), some of patients were diagnosed with mild intermittent bronchial asthma (21,9%). The formation of bronchial asthma was observed in children with allergic diseases who did not receive montelukast – in 32% of patients, and in 15% of children who received montelukast, the difference is reliable. Prescription of montelukast for children with recurrent laryngotracheitis in combination with allergic diseases, family history of atopy, and the monitoring of an allergist are recommended.

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Chuvirova AG, Yartsev MN. Antileukotriene drugs in treatment of recurrent laryngotracheitis in children with allergic diseases for prevention of lower respiratory airways obstruction. Allergology and Immunology in Pediatrics. 2021;64(1):44-52. https://doi.org/10.24412/2500-1175-2021-1-44-52

For correspondense

Anastasia G. Chuvirova, allergist-immunologist of SSC «Institute of Immunology FMBA», Moscow, Russia
ORCID: 0000-0002-5524-5406
Address: Kashirskoe shosse, 24, Moscow, 115478, Russia
E-mail: anastasia.chouvirova@gmail.com

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