Interleukin-5 levels depending on the severity of atopic dermatitis

O.S. Prylutskyi, K.Y. Tkachenko

State Educational Institution of Higher Professional Education «M. Gorky Donetsk National Medical University», Donetsk, Donetsk People’s Republic

ALLERGOLOGY AND IMMUNOLOGY IN PEDIATRICS, Volume 56 • Number 1 • March 2019, pp. 19 – 27
DOI: 10.24411/2500-1175-2019-00003

Atopic dermatitis is one of the most common alergic diseases of childhood. A number of studies have reported on the role of T-helper type 2 and cytokines synthesized by them in the pathogenesis of atopic dermatitis. This data is devoted to the study of the possible links of interleukin – 5 and the severity of clinical manifestations of atopic dermatitis. We interviewed and examined 84 patients suffering from atopic dermatitis. The control group consisted of 68 healthy individuals. In al examined patients the severity index of atopic dermatitis SCORAD were calculated and the serum levels of interleukin-5 were determined. The paired comparisons of the values of interleukin – 5 were made depending on the severity of atopic dermatitis. The Kendal rank correlation coefficient between the level of interleukin – 5 and the SCORAD index was calculated. It was established that the level of the above cytokine is significantly higher (p <0.001) in the examined patients with atopic dermatitis compared with control group. Interleukin – 5 levels were found to be significantly (p = 0.014) higher in patients with severe atopic dermatitis compared with patients with mild and moderate course of the disease. A direct correlation between the atopic dermatitis severity indices SCORAD and interleukin-5 (p = 0.02) was also revealed. The data from our study confirm the importance of the effect of interleukin-5 on the severity of clinical manifestations of atopic dermatitis.

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Prylutskyi OS, Tkachenko KY. Interleukin-5 levels depending on the severity of atopic dermatitis. Allergology and Immunology in Pediatrics. 2019;56(1):19-27. (In Russ.)

For correspondense

O.S. Prylutskyi