Eosinophilic esophagitis in a boy of 10 years. Clinical case

D.Sh. Macharadze 1, I.A. Larkova 2, V.A. Revjakina 2, V.I. Peshkin 1, I.S. Sadikov 3

1 Рeoples Friendship University of Russia (RUDN University), SM-clinic, Moscow, Russia
2 Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia
3 Clinical Hospital № 17, Moscow, Russia

ALLERGOLOGY AND IMMUNOLOGY IN PEDIATRICS, Volume 53 • Number 2 • June 2018, pp. 21 – 25
DOI: 10.24411/2500-1175-2018-00008

Eosinophilic esophagitis (EoE) belongs to the group of gastrointestinal eosinophilic diseases, which is rarely diagnosed in real clinical practice by Russian doctors, especially in children. Initially, EoE was considered a predominantly childhood disease. EoE should be suspected in patients with allergic diseases (most often male) and in combination with dysphagia and/or other complaints from the gastrointestinal tract. Over time and, especially, with inadequate therapy, EoE is accompanied by the formation of strictures and fibrous changes in the esophageal tissue. EoE is a clinical and morphological diagnosis, which requires a biopsy of the esophageal mucosa, which reveals an increase in the level of eosinophils (≥15 in sight, x 400) in the esophageal tissue (without other alternative causes of eosinophilia).

  1. Eosinophilic esophagitis: updated consensus recommendations for children and adults / C.A. Liacouras, G.T. Furuta, I. Hirano et al. // J. Allergy Clin.Immunol. 2011. Vol. 128. P. 3–20.
  2. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults / J.Lucendo, J.Molina-Infante, Á.Ariaset al.// United Eur.Gastroenterol. J. 2017. Vol. 5. P.335–358
  3. ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE) / E.S.Dellon, N.Gonsalves, I. Hirano et al. // Am. J.Gastroenterol. 2013. Vol. 108. P. 679–692.
  4. Management guidelines of eosinophilic esophagitis in childhood / A.Papadopoulou, S.Koletzko, R.Heuschkel et al.// J. Pediatr.Gastroenterol.Nutr. 2014.Vol. 58. P. 107–118.
  5. Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system / I.Hirano,N.Moy, M.G.Heckman et al. // Gut. 2013.Vol. 62. P. 489–495.
  6. Symptoms have modest accuracy in detecting endoscopic and histologic remission in adults with eosinophilic esophagitis /E.Safroneeva, A.Straumann, M.Coslovsky et al. // Gastroenterology. Vol. 150. P. 581–590.
  7. Садиков И.С., Мачарадзе Д.Ш., Хомерики С.Г. Особенности диагностики эозинофильного эзофагита // Экспериментальная и клиническая гастроэнтерология. 2015. № 2 (114). С. 52–59.
  8. Мачарадзе Д.Ш. Пищевая аллергия у детей и взрослых. Клиника, диагностика, лечение. М., Гэотар, 2017. 391 с.
  9. Мачарадзе Д.Ш. Эозинофильные гастроинтестинальные болезни у детей. Пора ставить диагноз // Лечащий врач. 2016. № 1. С. 41.
  10. Adherence to Celiac Disease and Eosinophilic Esophagitis Biopsy Guidelines Is Poor in Children / T.Wallach, R.Genta, B.Lebwohlet al.//J. Pediatr.Gastroenterol.Nutr. 2017.Vol. 65. P. 64–68.

Macharadze DSh, Larkova IA, Revjakina VA, Peshkin VI, Sadikov IS. Eosinophilic esophagitis in a boy of 10 years. Clinical case. Allergology and Immunology in Pediatrics. 2018;53(2):21-25. (In Russ.) https://doi.org/10.24411/2500-1175-2018-00008

For correspondense

D.Sh. Macharadze
e-mail: dalim_a@mail.ru.

I.A. Larkova
e-mail: inna_larkova@mail.ru.

V.A. Revjakina
e-mail: 5356797@mail.ru.

V.I. Peshkin
e-mail: medfac@yandex.ru.

I.S. Sadikov
e-mail: i.s.sadikov@yandex.ru.