Allergic rhinitis in children with overweight/obesity: features of sensitization

V.V. Bekezin1, A.E. Koroleva1, L.V. Sazonenkova2, E.V. Volkova2, R.Y. Meshkova1

1 Smolensk State Medical University, Smolensk, Russia;
2 Smolensk regional center of Allergology and Immunology, Smolensk, Russia

ALLERGOLOGY AND IMMUNOLOGY IN PEDIATRICS, Volume 63 • Number 4 • December 2020, pp. 29-35
DOI: 10.24411/2500-1175-2020-00010

Relevance. In the literature there are single works dedicated to the study of allergic rhinitis in children with overweight and obesity. The available information are conflicting and require further study.
Aim of study. To study the nature of sensitization to aeroallergens and the debut of allergic rhinitis in children with overweight/obesity.
Materials and methods. The study included 45 children with allergic rhinitis (AR) at the age of 4–8 years, who were monitored at the Smolensk Regional Center of Allergology and Immunology; the selection of children was carried out by the method of continuous sampling. The SDS criterion (body weight, kg / height, m) was used to assess body weight. The results were evaluated by the data of percentile tables and / or standard deviation scores depending on the child’s age and gender differences. Obesity in children was diagnosed at +2.0 SDS. All children were divided into 3 groups: 1st — 22 children with normal body weight, 2nd — 13 children with SDS below normal and 3rd — 10 children with overweight/obesity. All children spent skin scarification allergy tests with water-salt extracts of house dust mites (HDM) and pollen allergens (manufactured by JSC “Biomed” Russia) according to the standard method Positive results of allergy tests to one allergen were considered as monosensitization, to two or more allergens — as polysensitization. The presence of positive allergy tests to non-closely related allergens (pollen, KDP) was considered as a combined sensitization [1]. Statistical working of the results was carried out using the statistical software package Microsoft Excel 7.0. The angular transformation test (Fisher’s test) or the χ2 test (X-square) were used to compare the proportional indicators between the groups. The results were considered reliable at a significance level of p<0,05.
Results. We found as a result of research that overweight / obesity meets about 1/5 of children 4–8 years old with allergic rhinitis. The debut of allergic rhinitis did not depend on the child’s body weight. Boys predominated in all groups of children with allergic rhinitis whatever of body weight. Hypersensitivity to house dust mite allergens is the leading cause of allergic rhinitis in children 4–8 years old in all weight categories (from 60,0% to 69,2%). Allergic rhinitis in children with overweight / obesity conditioned as 2,64 times often (p<0.05) by monosensitization to aeroallergens compared with children with normal SDS. Whereas children with normal body weight is recorded 2,05 times more often (p<0.05) the combined type of hypersensitivity.
Conclusion. Obesity meets in 1/5 of children 4–8 years old with allergic rhinitis. This factor did not affect the debut of allergic rhinitis, but influenced on the type of sensitization to aeroallergens.

  1. Ахапкина И.Г., Краханенкова С.Н., Добронравова Е.В. и др. Изучение профиля гиперчувствительности к пыльцевым и грибным аллергенам в Московском регионе//Клиническая и лабораторная диагностика, 2014, № 5, с. 41–43. [Ahapkina I.G., Krahanenkova S.N., Dobronravova E.V. i dr. Izuchenie profilya giperchuvstvitel’nosti k pyl’cevym i gribnym allergenam v Moskovskom regione//Klinicheskaya i laboratornaya diagnostika, 2014, № 5, s. 41–43. (InRuss)].
  2. Elizabeth Huiwen Tham, Alison Joanne Lee, Hugo Van Bever. Aeroallergen sensitization and allergic disease phenotypes in Asia //Asian Pac J Allergy Immunol 2016; 34: 181–189. DOI 10.12932/AP0770
  3. Weihao Wang, Xuekun Huang, Zhuanggui Chen et al. Prevalence and trends of sensitisation to aeroallergens in patients with allergic rhinitis in Guangzhou, China: a 10-year retrospective study //BMJ Open 2016;6:e011085. doi:10.1136/bmjopen-2016-011085
  4. Michael Katotomichelakis, Theodoros Iliou, Ioannis Karvelis et al. Symptoms and allergic rhinitis in children and adolescents //Med Sci Monit, 2017; 23: 4939–4946.
  5. A Valero ,S Quirce, I Dávila et al. Allergic respiratory disease: Different allergens, different symptoms/ 2017 Sep; 72(9): 1306–1316. doi: 10.1111/all.13141. Epub 2017 Mar 17.
  6. V Siroux, N Ballardini, M Soler et al. The asthma-rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults //Allergy. 2018 Jul; 73(7):1447–1458. doi: 10.1111/all.13410. Epub 2018 Feb 6.
  7. Danielle Saadeh, Pascale Salameh, Denis Caillaud et al. High body mass index and allergies in schoolchildren: the French six cities study // BMJ Open Resp Res 2014; 1: e000054. doi:10.1136/bmjresp-2014-000054.
  8. R.Umano, C. Pistone, E. Tondina et al. Pediatric Obesity and the immune system //Frontiers in pediatrics. November 2019, vol. 7, article 487.
  9. Kristine Kjer Byberg, Geir Egil Eide, Michele R. Forman et al. Body mass index and physical activity in early childhood are associated with atopic sensitization, atopic dermatitis and asthma in later childhood //Clin Transl Allergy (2016) 6:33 DOI 10.1186/s13601-016-0124-9 10.
  10. Yang Lei, Huang Yang, Long Zhen. Obesity is a risk factor for allergic rhinitis in children of Wuhan (China) //Asia Pacific allergy. 2016; 6: 10.
  11. You Yang, Manli Gu. Association of body mass index and season with histamine skin reactivity in Chinese children with allergic rhinitis // Pediatr Neonatol. 2019 Apr; 60(2): 172– doi: 10.1016/j.pedneo.2018.05.011. Epub 2018 May 31.
  12. Adam J. Sybilski, Filip Raciborski, Aneta Tomaszewska et al. Obesity — a risk factor for asthma, but not for atopic dermatitis, allergic rhinitis and sensitization //Public Health Nutr.2015 Feb;18(3): 530–6.
  13. Балаболкин И.И., Ксензова Л.Д., Беляева Е.В. Поллинозы у детей и подростков // Педиатрическая фармакология, 2007, Т 4, № 2, С. 66–70. [Balabolkin I.I., Ksenzova L.D., Belyaeva E.V. Pollinozy u detej i podrostkov // Pediatricheskaya farmakologiya, 2007, Т 4, № 2, S. 66–70. (InRuss)].
  14. A. Lucas, S. Moonie, K. Olsen-Wilson et al. Asthma, allergy and obesity: examining the relationship among Nevada children //J. Asthma 2017 Aug, 54(6):594–599.

Bekezin VV, Koroleva AE, Sazonenkova LV, Volkova EV, Meshkova RY. Allergic rhinitis in children with overweight/obesity: features of sensitization. Allergology and Immunology in Pediatrics. 2020;63 (4):29-35.

For correspondense

Raisa Y. Meshkova, Professor, MD, DSc. Head of the Department of Clinical Immunology and Allergology, Smolensk State Medical University
ORCID: 0000-0002-7806-9484
Address: Krupsray 28, Smolensk, 214019, Russia


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