Changes in basophil reactivity and synthesis of specific immunoglobulins E influenced by allergen-immunotherapy

L.Yu. Barycheva^1,2, L.V. Dushina¹, Yu.N. Medvedenko^1,2

¹Federal State Budgetary Institution for Higher Education Stavropol State Medical University of the Ministry of Health, Russian Federation; Department of Immunology; Stavropol, Russia;
²Stavropol Regional Clinical&Counseling Diagnostics Center; Stavropol, Russia;

ALLERGOLOGY AND IMMUNOLOGY IN PEDIATRICS, Volume 64 • Number 1 • March 2021, pp. 15-23
DOI: 10.24412/2500-1175-2021-1-15-23

Abstract

The study focused on spontaneous and allergen-induced basophil activation (BAT) as well as on specific IgE indicators to major meadow grass pollen allergens on the background of allergen-immunotherapy (AIT) in patients sensitized to weed pollen.
The study revealed that the specific IgE indicators to major ragweed allergens (nAmb a 1) and wormwood (nArt v 1) allergens, as well as the ratios of spec. IgE nAmb a 1 / gen. IgE, and spec. IgE nArt v 1 / gen. IgE do not change after 2 courses of pre-seasonal ASIT. There was a decrease detected in BAT indicators under the effect of ASIT. An early decrease in the BAT stimulation index (BAT IC) was shown to be more common for patients with positive treatment outcomes.

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Barycheva LYu, Dushina LV, Medvedenko YuN. Changes in basophil reactivity and synthesis of specific immunoglobulins e influenced by allergen-immunotherapy. Allergology and Immunology in Pediatrics. 2020;1(64):15-23. https://doi.org/10.24412/2500-1175-2021-1-15-23

For correspondense

Liudmila Yu. Barycheva, MD, Professor, Head of the Department of Immunology with a course of continuing professional education at Stavropol State Medical University
ORCID: 0000-0002-4069-0566
Address: 310 Mira street, 355017, Stavropol, Russia
E-mail: for_ludmila@inbox.ru