Clinical and immunological features of bronchial asthma phenotype with obesity in children

E.V. Churyukina, A.A. Lebedenko, G.A. Galkina, M.V. Dudareva, M.A. Levkovich

Rostov State Medical University, Rostov-on-don, Russia

ALLERGOLOGY AND IMMUNOLOGY IN PEDIATRICS, Volume 54 • Number 3 • September 2018, pp. 14 – 20
DOI: 10.24411/2500-1175-2018-00012

The paper presents the results of a study of 82 adolescents aged 12 to 16 years, of which 42 patients suffering from bronchial asthma (BA), divided into 2 groups, taking into account the z-Score index (SDS BMI), and 40 healthy children without respiratory pathology, with normal body weight (SDS BMI 0-1), who made up the control group. General clinical, anamnestic features, parameters of external respiration function, cytokine and immune statuses of each group of children were studied. Identified the clinical features of this phenotype of asthma and changes of the immune status of patients with bronchial asthma with obesity, namely: stimulation of T – and b-cellular link; increased parameters of oxidative metabolism of neutrophils, decreased reserve capacity of oxygen-dependent phagocytosis, which in combination with elevated concentrations of proinflammatory cytokines (IL-6, TNF) and CRP, as well as serum IgA levels, total IgE in comparison with the data of patients without obesity BA and control group – associated with systemic inflammation, leading to increased activity of allergic inflammation of the respiratory tract. In this case, the correlation analysis revealed a strong direct relationship between b-lymphocytes (CD19+) and the index of the ratio of waist (WS) and hip volume (HV), indicating the ability of abdominal fat deposition to activate, including the humoral link of the immune system.

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Churyukina EV, Lebedenko AA, Galkina GA, Dudareva MV, Levkovich MA. Clinical and immunological features of bronchial asthma phenotype with obesity in children. Allergology and Immunology in Pediatrics. 2018;54(3):14-20. (In Russ.)

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E.V. Churyukina


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