Predictive significance of pro-inflammatory interleukins at newborns with hypoxic-ischemic encephalopathy


Volume 67 • Issue 4 • December 2021, pp. 12-19

Received: 27.09.2021 | Accepted for publication: 14.11.2021 | ​Publication date: 25.12.2021

ORCID logo L.Yu. Barycheva 1, ORCID logo A. S. Idrisova 2, E. S. Kuzmina 1,3, ORCID logo O. V. Agranovich 1,3ORCID logo K. S. Mezhidov 2

1 Federal State Budgetary Institution for Higher Education Stavropol State Medical University of the Ministry of Health, Russian Federation; Department of Immunology; 310, Mira st., Stavropol, 355002, Russia
2 Republican Children’s Clinical Hospital named after E.P. Glinka, Chechenskaya Respublika, 101 ul. I.I. Bisultanova, Grozny, 366041, Russia
3 Children’s Regional Clinical Hospital, 3 Semashko st., Stavropol, 355029, Russia

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Relevance. Hypoxic-ischemic damage to the central nervous system is accompanied by overproduction of pro-inflammatory interleukins in newborns. Perinatal inflammatory responses contribute to unfavorable outcomes.

Methods of investigation. The analysis of the cytokine profile in the blood serum was performed in 45 full-term newborns by the method of enzyme-linked immunosorbent assay within 4–96 hours after birth. 32 children had the signs of HIE stage 2, 13 children — HIE stage 3. Unfavorable neurological consequences were formed in 47,4% of children.

Research results. Revealed an increase in the levels of IL1β — 17,7 [13,6; 25,4] and IL6 35,2 [24,9; 45,0] in newborns with HIE. A significant increase in pro-inflammatory cytokines was found in patients with unfavorable outcomes compared with favorable ones. When predicting the disabling consequences of DIE, a high predictive value was established for IL1β and IL6.

Conclusion. In newborns with hypoxic-ischemic encephalopathy, an increase in serum IL1β and IL6 is observed. It is advisable to use an increase in IL1β >19,4 pg/ml (OR=12,80; 95% CI: 2,90–56,58) and IL6 >40,1 pg/ml (OR=11,33; 95% CI: 2,46–52,15).


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Barycheva LYu, Idrisova AS, Kuzmina ES, Agranovich OV, Mezhidov KS. Predictive significance of pro-inflammatory interleukins at newborns with hypoxic-ischemic encephalopathy. Allergology and Immunology in Pediatrics. 2021;4:12–19. (In Russ.)

For correspondence:

Liudmila Yu. Barycheva

Dr. of Sci., professor, Head of the Department of Immunology with a course of continuing professional education, Stavropol State Medical University, Russian Federation

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