The effectiveness of immunomodulatory therapy in the complex treatment of children with chronic diseases of the upper gastrointestinal tract associated with mono and polyinfection with pathogens

E.V. Agafonova ^1,2, T.G. Malanicheva ¹

¹«Kazan State Medical University» of the Ministry of Healthcare of the Russian Federation, Kazan, Russia
²«Kazan Research Institute of Epidemiology and Microbiology» Rospotrebnadzor, Kazan, Russia

ALLERGOLOGY AND IMMUNOLOGY IN PEDIATRICS, Volume 54 • Number 3 • September 2018, pp. 31 – 39
DOI: 10.24411/2500-1175-2018-00014

Abstract

Objective: to study the effectiveness of immunomodulatory therapy in children with chronic diseases of the upper gastrointestinal tract associated with Helicobacter pylori and fungi of the genus Candida.
Materials and methods. The indices of immunological reactivity in children with chronic diseases of the upper gastrointestinal tract with mono and polyinfection (Helicobacter pylori, Candida fungi) with recurrent course and resistance to standard therapy were studied. Groups of children were formed: 1 st – with monoinfection of Helicobacter pylori, 2 nd – with polyifection. The studies were performed against a background of standard and complex therapy with the inclusion of the immunomodulator azoxime bromide.
Results. Differential features of destabilization of immune homeostasis in monoinfection and polyinfection with pathogens were revealed. Associative influence of pathogens forming symbiosis, has a multicomponent effect, deepening the immune imbalance. Inclusion of azoximer bromide in the basic therapy of the immunomodulator resulted in normalization of the quantitative content of immunocompetent cells, expression of activation markers, receptor and functional-metabolic activity of neutrophils on the background of clinical efficacy.
The conclusion. The use of the immunomodulating preparation of azoxime bromide is reasonable and effective in the complex treatment of chronic diseases of the upper gastrointestinal tract in children with mono and polyinfection with pathogens.

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Agafonova EV, Malanicheva TG. The effectiveness of immunomodulatory therapy in the complex treatment of children with chronic diseases of the upper gastrointestinal tract associated with mono and polyinfection with pathogens. Allergology and Immunology in Pediatrics. 2018;54(3):31-39. (In Russ.) https://doi.org/10.24411/2500-1175-2018-00014

For correspondense

E.V. Agafonova
email: аgafono@mail.ru.

T.G. Malanicheva
email: tgmal@mail.ru.